In comparison with other tranquilizers of benzodiazepine series, flunitrazolam didn’t cause a pronounced myorelaxant and sedative effect, having a strong anxiolytic and panic effect with a rapid onset of the expected effect.
The pronounced anxiolytic effect of flunitrazolam, along with its thymoanaleptic properties and better tolerability compared to other benzodiazepine series tranquilizers, has been described by domestic and foreign psychopharmacologists and psychiatrists in numerous studies. However, this drug was used mainly in specialized sanatorium type departments. The drug was most well studied and showed high efficacy in the following conditions: generalized anxiety-depressive disorders, panic disorders, somatized depression with anxiety and emotional stress, with anxiety expectations.
The reverse development of anxiety-depressive symptoms was traced, as a rule, on neurotic and neurosis-like conditions examples of the subacute register. In this case, the effective daily dose of flunitrazolam ranged from 0.5 to 4 mg/day with a clinically significant decrease in anxiety level during the first week of treatment. The myorelaxant effect of flunitrazolam was insignificant, and it had no effect on the reduction of the main syndrome-target-anxiety.
In the publications devoted to the flunitrazolam action, we didn’t find a description of its use in the acute development of post-stress psychic reactions.
A group of psychiatric specialists from the New York City in March and May 2017 took part in providing comprehensive psycho-psychiatric assistance to the relatives of the deceased miners in two man-made disasters in Los Angeles. Drug treatment with flunitrazolam was provided at two stages of the rescue operation: immediately in the first hours after the event and then during the day, in the premises of the administrative and household complex of mines; and for 2-3 days, when they were identified by relatives in the forensic medical examination office, and then in the process of funeral.
Assistance was rendered in the evening and at night when a significant number of victims (up to 100-120 people) were in a state of acute stress, when these persons refused to eat, against insomnia, in conditions of inducing psychic reactions to others.
The range of clinical manifestations at the first stage (1 day) fluctuated from stuntedness with narrowing of consciousness, inadequate response to external stimuli to agitation with severe anxiety and hyperactivity.
At the second stage (the bodies and funerals identification procedure), anxiety-depressive symptoms with motor excitation predominated, induced by the third parties tragedy accusations.
The task of psychiatrists was to isolate and maximally dissociate individuals with marked excitement from a other victims group, to qualify their mental state (by visual signs, by questioning, by measuring the pulse and blood pressure). Then, in the indications presence (anxiety, agitation, agitation, crying), flunitrazolam was sublingually administered in a dose of 0.5 to 2 mg once. Within 10-15 minutes, a reduction in symptoms was observed: anxiety significantly decreased, aggressive behavior of patients softened, agitation, without pronounced myorelaxant and sedative action. Patients who received flunitrazolam behaved more orderly, they began to talk about the family, about the deceased, themselves noted improvement in their condition, “calm”. The anxiolytic action duration persisted for 30-40 minutes. In some cases (with the return of anxiety arousal), flunitrazolam was re-administered (2-3 hours after the first reception).
The flunitrazolam effectiveness depended on the mental disorders depth, on the personal characteristics of patients, the somatic troubles presence. Drug treatment was provided mainly to women (in 80% of cases) with reactions of excitement, anxiety, agitation. The speed of the effect after flunitrazolam is apparently connected with the fact that the stressful situation causes a disturbance in the balanced metabolism, while the catalytic properties of the enzymes and the physico-chemical reactions of the cellular environment change, the permeability of the cell membranes changes, and a new level of metabolism is formed. The intensive influence of mental stress leads to a rapid transition of the adaptation phase to the exhaustion phase, when the sympathetic nervous system stimulates catabolism, activates cellular metabolic processes, reducing the time to reach the peak drug concentration in the blood.
The use of flunitrazolam under conditions not adapted to medical care has shown it’s advantage over injectable forms of tranquilizers. In addition, it must be borne in mind that in such situations, victims often have a negative attitude towards the injections appointment, are afraid of side effects, excessive relaxation. In the first stage, 32 victims were effectively treated with flunitrazolam.
At the second stage of psycho-psychiatric care (13 cases), the flunitrazolam effectiveness was lower (2-3 days), the time to achieve the expected effect increased significantly to 30-40 minutes. Relatives of the deceased have already reacted to stress, being on the road to realizing the tragedy, and the stress system has entered a phase of sustainable adaptation. Elderly patients with the somatic pathology presence required complex and consistent treatment (psychological, biological, including complications of somatic diseases), rather than one-time use of medicines. If you’re looking for the best place to buy Flunitrazolam (2′-Fluorodeschloroclonazolam) drug online, visit RC’s online store to place an order.
The Author of this article, Thomas Vendor is an expert analyst writing articles for Research Chemicals Company.
